Progynon Depot 10mg/mL (Estradiol Valerate) is used to replenish the loss of estrogen during menopause which leads to symptoms of hot and cold flushes, mood swings, night sweats, vaginal dryness, headaches, loss of energy, itching and burning. Intake of this medicine helps with postmenopausal bone loss or osteoporosis, thus lessening the risk of fracture. Young women who do not have enough estrogen production in their ovaries either naturally or due to ovaries being removed surgically also use it as hormone replacement treatment. It is also quite effective in the treatment of certain strains of prostate cancer. Transgender hormone therapy uses this medicine to develop female sexual characteristics.
Dosage and Administration
Progynon Depot 10mg/mL (Estradiol Valerate) is given as an injection into the muscle. The usual dosage is once every 1 to 2 weeks or even every 4 weeks but always under the guidance of a doctor. The doctor will advise about the start date as well as cycle. The length of treatment will of course depend upon the response to therapy.
The most common side effects associated with Progynon Depot 10mg/mL are:
- Breast pain or tenderness
- Hair loss
- Breakthrough bleeding
- Upset stomach
Less common side effects you may experience include:
- Breast lumps
- Bulging eyes
- Blood clots
- Rapid weight changes
Progynon Depot 10mg/mL could increase your susceptibility to ovarian cancer or gallbladder disease. If used in children, it could arrest growth and affect the speed and timing of sexual development. It is advisable to proceed to the emergency room for immediate treatment for any allergic reactions like hives, swelling, and such.
Before taking Progynon Depot 10mg/mL, you should advise your doctor if you:
- Are pregnant or lactating
- Are on other medications or herbal supplements
- Are trying to conceive
- Have DVT or thromboembolic disorders
- Are a diabetic on insulin or other drugs
- Have a family history of breast carcinoma, liver disease, or endometrial carcinoma.
Drug Interactions with Estradiol Valerate
Anticonvulsants like carbamazepine, anti-virals like nevirapine, antibiotics like penicillin, and barbiturates may interact with estradiol valerate.