Duloxetineæis used to treatædepressionæandæanxiety. In addition, duloxetine is used to help relieveænerve painæ(peripheral neuropathy) in people withædiabetesæor ongoing pain due to medical conditions such asæarthritis, chronicæback pain, oræfibromyalgiaæ(a condition that causes widespread pain).
Duloxetine may improve your mood,æsleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). Thisæmedicationæworks by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in theæbrain.
See also Warning section.
Nausea,ædry mouth,æconstipation, loss of appetite, tiredness, drowsiness, or increasedæsweatingmay occur. If any of these effects persist or worsen, tell your doctor promptly.
Dizzinessæorælightheadednessæmay occur, especially when you first start or increase your dose of this drug. To reduce the risk of dizziness, lightheadedness, or falling, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed thisæmedicationæbecause he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This medication may raise youræblood pressure. Check youræbloodæpressure regularly and tell your doctor if the results are high.
Tell your doctor right away if any of these serious side effects occur: confusion, easy bruising/bleeding, decreased interest inæsex, changes in sexual ability,æmuscle cramps/weakness, shaking (tremor), difficulty urinating, signs ofæliveræproblems (such asæstomach/abdominal pain, persistentænausea,ævomiting, yellowingæeyes/skin, dark urine).
Get medical help right away if you have any very serious side effects, including: black/bloody stools, vomit that looks like coffee grounds,æseizure,æeye pain/swelling/redness, widened pupils,ævisionæchanges (such as seeing rainbows around lights at night,æblurred vision).
This medication may increase serotonin and rarely cause a very serious condition calledæserotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor oræpharmacistæof all the drugs you take (seeæDrug Interactionssection). Get medical help right away if you develop some of the following symptoms: fast heartbeat,æhallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea,ætwitchingæmuscles,æunexplained fever, unusual agitation/restlessness.
A very seriousæallergic reactionæto this drug is rare. However, get medical help right away if you notice any symptoms of a seriousæallergic reaction, including:ærash,æitching/swelling (especially of the face/tongue/throat), severe dizziness,ætrouble breathing, skinæblisters,æmouthæsores.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.